In the United States, chronic kidney disease is very common. Patients who have chronic kidney disease typically also have a number of other co-morbid conditions. As a result, these patients typically take more than one medication for the management of their chronic condition, which may include medications for high blood pressure, diabetes, and other conditions. Because of the decline in kidney function, the dosages of the medications used to treat these chronic conditions need to be carefully adjusted in order to prevent adverse drug reactions. In addition, it is important to note that patients who have advanced chronic kidney disease should not take certain medications. It is essential for primary care providers to have an understanding of the various stages of chronic kidney disease and the ability to adjust medications based on how well the kidneys are functioning. In addition to this, it is essential you correctly diagnose patients who have drug interactions and toxicities, particularly those patients whose kidney function is compromised.